The Hidden Brain Changes of Alzheimer’s—Before Symptoms Start
Published in Healthcare & Nursing, Neuroscience, and General & Internal Medicine
Alzheimer’s disease doesn’t begin when symptoms show up—changes can start quietly years earlier. In this study of almost 1,000 older adults with normal cognition, we combined resting-state brain scans with biomarkers from cerebrospinal fluid to look for early warning signs. We found that certain brain networks—especially those involving the precuneus and parts of the default mode network—showed subtle, non-linear changes linked to amyloid, a key Alzheimer’s-related protein. Importantly, the strength of communication in these networks was related to better performance on memory and thinking tests. These results suggest that early Alzheimer’s-related changes may be detectable as shifts in brain network “wiring,” even before any noticeable cognitive decline.
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Alzheimer's Research & Therapy
Alzheimer's Research & Therapy is the major forum for translational research into Alzheimer's disease. Affiliated with Alzheimer’s Disease International (ADI), we publish basic research, as well as clinical trials, research into drug discovery and development, and epidemiologic studies.
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This is a sister Collection with Engineering TMS-Based Neurorehabilitation: Innovations for Functional Restoration in Neurological Disorders in Journal of NeuroEngineering and Rehabilitation.
This Collection supports and amplifies research related to SDG 3, Good Health and Well-Being.
All submissions in this Collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (details here). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visit OA funding and support, or email OAfundingpolicy@springernature.com or the Editor-in-Chief.
Publishing Model: Open Access
Deadline: Nov 27, 2026
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