Behind the Paper

Preserving anti melanoma immunity by nanoparticle-mediated cAMP repression

Published in Cancer

Go to the profile of Christian Becker
Christian Becker
Group Leader, Department of Dermatology, University Hospital Münster
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Nature
Nature Nature

Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression - Nature Communications

The acidic tumour microenvironment in melanoma drives immune evasion by cAMP in tumor-infiltrating monocytes. Here, the authors show that the release of an adenylate cyclase inhibitor from micelles restores antitumor immunity and, when combined with regulatory T cell depletion, leads to remission of established B16-F10-OVA tumors.
Go to the profile of Christian Becker
Christian Becker
Group Leader, Department of Dermatology, University Hospital Münster

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Cancer Biology
Life Sciences > Biological Sciences > Cancer Biology

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