Integrative genomic and functional characterization of FAM3 family genes reveals their diagnostic and prognostic roles in kidney renal clear cell carcinoma
Published in Cancer
Kidney renal clear cell carcinoma (KIRC) is the most common and aggressive form of kidney cancer, often diagnosed at advanced stages with limited treatment options and poor prognosis. Despite advances in surgery and targeted therapies, reliable molecular markers for early diagnosis, prognosis, and therapy guidance remain scarce. The FAM3 (Family with Sequence Similarity 3) gene family, consisting of FAM3A, FAM3B, FAM3C, and FAM3D, has been implicated in diverse biological processes including metabolism, cytokine signaling, and cellular differentiation, yet their roles in KIRC are largely unexplored.
Given the critical need to uncover molecular drivers of KIRC, this study aimed to systematically investigate the expression, epigenetic regulation, and functional impact of FAM3 family genes in KIRC. By integrating large-scale genomic datasets, the study examined differential expression patterns, promoter methylation, and genetic alterations of FAM3 genes in tumor versus normal tissues. The analysis also explored associations with patient survival, immune infiltration, and potential therapy responsiveness.
In addition to computational analyses, functional experiments in KIRC cell lines were conducted to validate the roles of FAM3 genes in tumor cell proliferation, migration, and drug sensitivity. This integrative approach provides a holistic understanding of how FAM3 genes contribute to KIRC biology and identifies their potential as diagnostic and prognostic biomarkers. Overall, the study highlights the FAM3 family as a promising avenue for improving personalized therapy and understanding tumor progression in kidney cancer.
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Cytotechnology
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