Investigating the impact of IKZF1 SNPs rs4132601 and rs11978267 on acute lymphoblastic leukemia: a comprehensive meta-analysis

Leukemias are a diverse group of hematologic disorders primarily affecting white blood cells, with varying clinical presentations, prognoses, and responses to treatment.

Published in Cancer

Go to the profile of Dr. Ramakrishnan Veerabathiran
Dr. Ramakrishnan Veerabathiran
Associate Professor in Genetics, Chettinad Academy of Research and Education
Investigating the impact of IKZF1 SNPs rs4132601 and rs11978267 on acute lymphoblastic leukemia: a comprehensive meta-analysis
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SpringerOpen

Investigating the impact of IKZF1 SNPs rs4132601 and rs11978267 on acute lymphoblastic leukemia: a comprehensive meta-analysis - Journal of the Egyptian National Cancer Institute

Objective This meta-analysis investigates the association between acute lymphoblastic leukemia (ALL) susceptibility and IKZF1 gene SNPs. Methods Utilizing EMBASE, PubMed, and other databases, the study evaluated methodological quality through the Newcastle–Ottawa Scale (NOS) scoring and Hardy–Weinberg Equilibrium (HWE) value. The present meta-analysis used Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Review Manager 5.4 software was employed for data analysis, emphasizing genetic variants’ significance (p < 0.05). Visualizations were achieved using funnel and Circos plots. Results A significant association was found between rs4132601 and ALL across genetic models, contrasting with the non-significant correlation for rs11978267. The findings underscore the complex interplay of genetic factors in ALL susceptibility, particularly related to IKZF1 SNPs. Ethnicity emphasizes the importance of diverse population considerations. Conclusion This meta-analysis highlights the significance of rs4132601 in ALL’s genetic foundation, suggesting potential advancements in diagnostics. The lack of correlation for rs11978267 highlights the complexity of its genetic association. Future studies should prioritize larger, diverse samples for a comprehensive understanding and improved strategies for ALL diagnoses and treatments.

The article titled "Investigating the Impact of IKZF1 SNPs rs4132601 and rs11978267 on Acute Lymphoblastic Leukemia: A Comprehensive Meta-Analysis" concludes that both rs4132601 and rs11978267 polymorphisms in the IKZF1 gene are significantly associated with an increased risk of developing acute lymphoblastic leukemia (ALL), particularly in certain ethnic populations. The meta-analysis, which included data from numerous case-control studies, discovered that the existence of risk alleles for these SNPs correlated with an increased susceptibility to ALL, implying that they might serve as genetic biomarkers for early diagnosis and risk stratification in clinical practice.

Go to the profile of Dr. Ramakrishnan Veerabathiran
Dr. Ramakrishnan Veerabathiran
Associate Professor in Genetics, Chettinad Academy of Research and Education

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