Behind the Paper

Modeling the Invasive Progression of Human Cancer

Surgical generation of orthotopic xenograft models that recapitulate the invasive progression of human bladder cancer.
Published in Protocols & Methods
Go to the profile of Guadalupe Lorenzatti Hiles
Guadalupe Lorenzatti Hiles
Senior Research Fellow, University of Michigan
Modeling the Invasive Progression of Human Cancer
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Nature
Nature Nature

A surgical orthotopic approach for studying the invasive progression of human bladder cancer - Nature Protocols

A small laparotomy is carried out, and human cancer cells are implanted into the mouse bladder lumen. This reproduces the pathobiological events of human bladder cancer invasion in mice.





References: 

1          Lorenzatti Hiles, G., Cates, A.L., El-Sawy, L. et al. A surgical orthotopic approach for studying the invasive progression of human bladder cancer. Nat Protoc 14, 738–755 (2019).

Go to the profile of Guadalupe Lorenzatti Hiles
Guadalupe Lorenzatti Hiles
Senior Research Fellow, University of Michigan

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Biological Techniques
Life Sciences > Biological Sciences > Biological Techniques

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