S-Adenosyl-L-methionine methylene radical-mediated cyclopropanation in nature
A HemN-like radical S-adenosyl-L-methionine (SAM) enzyme adds a SAM-based methylene radical generated via a radical relay to an sp2 carbon of substrate to produce a SAM-substrate covalent adduct, which is converted to the cyclopropane ring by a methyltransferase in the biosynthesis of natural product CC-1065.
