Tien-Hsien Chang

Deputy Director, Genomics Research Center, Academia Sinica, Taipei, Taiwan

About Tien-Hsien Chang

RNA biology, Pre-mRNA splicing, RNA helicases, DExD/H-box proteins, Spliceosome evolution, Hepatitis C Virus, Yeast double-stranded RNA viruses, Evolutionary biology, Yeast Genetics

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Behind the Paper

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Mar 07, 2019

Dear Dr. Du,

I read your paper with great interest.  I have been interested in this question for a long long time and pursued that question in a similar manner using budding yeast for several years, but we failed in the end (I will spare you all the gory details).  But the question never left my mind. 

From there, we developed a different line of inquiry, which led to a related paper recently published in Nature Ecology and Evolution.  I think you might be interested in reading the paper:  https://www.nature.com/articles/s41559-018-0684-2?utm_source=Nature_community&utm_medium=Community_sites&utm_content=BenJoh-Nature-MultipleJournals-Evolutionary_Biology-Global&utm_campaign=MultipleJournals_USG_ECOEVO

I also wrote a blog at this very site, giving additional historical background that led us to where we are.

https://natureecoevocommunity.nature.com/users/62580-tien-hsien-chang/posts/39098-how-can-you-mend-a-broken-cell-let-experimental-evolution-show-you-how

It would be great to keep in touch.  You can easily reach me by the email address shown below.  Alternatively, you can find my professional info (phone number included) below:

http://www.genomics.sinica.edu.tw/2015/index.php/en/chang-tien-hsien

Best,

Tien-Hsien Chang

Deputy Director, Genomics Research Center, Academia Sinica, Taipei, Taiwan

chang108@gate.sinica.edu.tw

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