About Tien-Hsien Chang
RNA biology, Pre-mRNA splicing, RNA helicases, DExD/H-box proteins, Spliceosome evolution, Hepatitis C Virus, Yeast double-stranded RNA viruses, Evolutionary biology, Yeast Genetics
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Recent Comments
Dear Dr. Du,
I read your paper with great interest. I have been interested in this question for a long long time and pursued that question in a similar manner using budding yeast for several years, but we failed in the end (I will spare you all the gory details). But the question never left my mind.
From there, we developed a different line of inquiry, which led to a related paper recently published in Nature Ecology and Evolution. I think you might be interested in reading the paper: https://www.nature.com/articles/s41559-018-0684-2?utm_source=Nature_community&utm_medium=Community_sites&utm_content=BenJoh-Nature-MultipleJournals-Evolutionary_Biology-Global&utm_campaign=MultipleJournals_USG_ECOEVO
I also wrote a blog at this very site, giving additional historical background that led us to where we are.
https://natureecoevocommunity.nature.com/users/62580-tien-hsien-chang/posts/39098-how-can-you-mend-a-broken-cell-let-experimental-evolution-show-you-how
It would be great to keep in touch. You can easily reach me by the email address shown below. Alternatively, you can find my professional info (phone number included) below:
http://www.genomics.sinica.edu.tw/2015/index.php/en/chang-tien-hsien
Best,
Tien-Hsien Chang
Deputy Director, Genomics Research Center, Academia Sinica, Taipei, Taiwan
chang108@gate.sinica.edu.tw