Felix Ellett

Research Fellow, Massachusetts General Hospital
  • United States of America

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Behind the Paper

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Apr 19, 2018

Hi Veronika, 

Thank you for your interest! We got our fair share of critique, and responding definitely  improved our final manuscript. :) Most comments required clarification regarding how sepsis was defined in this study, how the patient cohorts were chosen, how the machine-learning approach was used etc. Some questions, like "what is in the plasma of sepsis patients that drives this neutrophil behaviour? Why don't you just measure that?" were outside the scope of the study, but of course are the subject of ongoing research! Whether or not our approach works as an early diagnostic in a broader cohort of at-risk patients is also a great question, and one that we are working on actively. 

Best, Felix