Cartilage targeting hydrogel nanoplatform degrades BRD4 to alleviate osteoarthritis via 1 Nav1.7 axis
Osteoarthritis is driven by epigenetic dysregulation, BRD4/Nav1.7 axis is associated with OA. We develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis. Animal experiments confirm the treatment is very effective.