TCF1 as a Key Regulator of the Hybrid EMT State in Breast Cancer: Balancing Self-Renewal and Differentiation
Triple-negative breast cancer (TNBC) harbor a unique hybrid epithelial/mesenchymal (E/M) subpopulation that conveys stemness and metastasis. Our work unravels a unique role for TCF1/Wnt/ERK/CDK4/6 signaling in driving the hybrid EMT state and its potential for therapeutic intervention in TNBC.