Rein in or Ruin: Ubiquitylation of CDC42 Ensures Membrane Homeostasis and Regulates Brain Development
The small Rho GTPase CDC42 drives actin polymerization and membrane protrusion. Unchecked cytoskeletal remodeling can push tumor cells toward EMT or even cell death. Thus, elucidating how cells both activate and quench CDC42 signaling to maintain membrane homeostasis has been a central question.
