Automated Cas13-based detection of SARS-CoV-2 in saliva

A COVID-19 test implemented in an automated microfluidic device and leveraging isothermal RNA amplification followed by T7 transcription and Cas13-mediated cleavage of a quenched fluorophore rapidly detects SARS-CoV-2 RNA in saliva samples.

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The cover illustrates a microfluidic cartridge for the automated amplification and detection of SARS-CoV-2 RNA in saliva via the Cas13-mediated cleavage of a quenched fluorophore.

See Chandrasekaran et al.

Image: Cyrus Tau, University of California, Berkeley. Cover design: Debbie Maizels

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Life Sciences > Biological Sciences > Biotechnology