‘Hit and run’ genome editing forestalls macular degeneration
Lentiviruses co-packaging SpCas9 mRNA and an expression cassette encoding for a guide RNA targeting the Vegfa gene prevent mice from developing wet age-related macular degeneration induced by Vegfa.
Published in Bioengineering & Biotechnology
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The cover illustrates that lentiviruses co-packaging SpCas9 mRNA and an expression cassette encoding for a guide RNA can transiently disrupt targeted disease-modifying genes.
See Ling et al.
Image: Yujia Cai and Sikai Ling, Shanghai Jiao Tong University. Cover design: Alex Wing.