‘Hit and run’ genome editing forestalls macular degeneration

Lentiviruses co-packaging SpCas9 mRNA and an expression cassette encoding for a guide RNA targeting the Vegfa gene prevent mice from developing wet age-related macular degeneration induced by Vegfa.
Like

Share this post

Choose a social network to share with, or copy the shortened URL to share elsewhere

This is a representation of how your post may appear on social media. The actual post will vary between social networks

Please sign in or register for FREE

If you are a registered user on Research Communities by Springer Nature, please sign in

Go to the profile of Pep Pàmies
over 3 years ago

The cover illustrates that lentiviruses co-packaging SpCas9 mRNA and an expression cassette encoding for a guide RNA can transiently disrupt targeted disease-modifying genes.

See Ling et al.

Image: Yujia Cai and Sikai Ling, Shanghai Jiao Tong University. Cover design: Alex Wing.

Follow the Topic

Biotechnology
Life Sciences > Biological Sciences > Biotechnology