Intratumoural activation of CAR T cells via focused ultrasound
The activity of engineered T cells within tumours can be controlled via the heat generated by pulses of focused ultrasound by modifying the cells to express a chimeric antigen receptor under the control of a promoter for the heat-shock protein.
Published in Bioengineering & Biotechnology
Chief Editor, Nature Biomedical Engineering, Nature Research
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Biotechnology
Life Sciences > Biological Sciences > Biotechnology
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Nature Biomedical Engineering
This journal aspires to become the most prominent publishing venue in biomedical engineering by bringing together the most important advances in the discipline, enhancing their visibility, and providing overviews of the state of the art in each field.
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The cover illustrates that T cells can be engineered to express a chimaeric antigen receptor within tumours when heat is locally generated by pulses of focused ultrasound.
See Wu et al.
Image: Lan-Tao Gou, Yinglin Situ and Yiqian Wu. Cover design: Allen Beattie.