Intratumoural activation of CAR T cells via focused ultrasound
The activity of engineered T cells within tumours can be controlled via the heat generated by pulses of focused ultrasound by modifying the cells to express a chimeric antigen receptor under the control of a promoter for the heat-shock protein.
Published in Bioengineering & Biotechnology
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Chief Editor, Nature Biomedical Engineering, Nature Research
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Life Sciences > Biological Sciences > Biotechnology
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Nature Biomedical Engineering
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The cover illustrates that T cells can be engineered to express a chimaeric antigen receptor within tumours when heat is locally generated by pulses of focused ultrasound.
See Wu et al.
Image: Lan-Tao Gou, Yinglin Situ and Yiqian Wu. Cover design: Allen Beattie.