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Prolonged local anaesthesia via nanofibres mimicking interactions on a sodium channel

A self-assembling supramolecular delivery system for site-1 sodium channel blockers designed to mimic specific interactions on voltage-gated sodium channels led to prolonged nerve blockade and to reduced systemic toxicity in rats.
Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research
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Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel - Nature Biomedical Engineering

A self-assembling supramolecular delivery system for site-1 sodium channel blockers designed to mimic specific interactions on voltage-gated sodium channels led to prolonged nerve blockade and to reduced systemic toxicity in rats.

The cover illustrates that self-assembled nanofibres carrying site-1 sodium channel blockers and designed to mimic specific interactions of the blockers with peptide sequences on voltage-gated sodium channels led to prolonged nerve blockade with low systemic toxicity in rats.

Image: Daniel S. Kohane, Harvard Medical School, Boston Children’s Hospital; Tianjiao Ji, National Center for Nanoscience and Technology; Xin Zhou, Fantastic Color Co., Ltd. Cover design: Allen Beattie.
Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research

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