Springer Nature Editor
From the Editors

Prolonged local anaesthesia via nanofibres mimicking interactions on a sodium channel

A self-assembling supramolecular delivery system for site-1 sodium channel blockers designed to mimic specific interactions on voltage-gated sodium channels led to prolonged nerve blockade and to reduced systemic toxicity in rats.
Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research
Like

Share this post

Choose a social network to share with, or copy the URL to share elsewhere

Share with...

...or copy the link

This is a representation of how your post may appear on social media. The actual post will vary between social networks

Explore the Research

Nature
Nature Nature

Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel - Nature Biomedical Engineering

A self-assembling supramolecular delivery system for site-1 sodium channel blockers designed to mimic specific interactions on voltage-gated sodium channels led to prolonged nerve blockade and to reduced systemic toxicity in rats.

The cover illustrates that self-assembled nanofibres carrying site-1 sodium channel blockers and designed to mimic specific interactions of the blockers with peptide sequences on voltage-gated sodium channels led to prolonged nerve blockade with low systemic toxicity in rats.

Image: Daniel S. Kohane, Harvard Medical School, Boston Children’s Hospital; Tianjiao Ji, National Center for Nanoscience and Technology; Xin Zhou, Fantastic Color Co., Ltd. Cover design: Allen Beattie.
Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research

Please sign in or register for FREE

If you are a registered user on Research Communities by Springer Nature, please sign in

Sign In Register

Follow the Topic

Biotechnology
Life Sciences > Biological Sciences > Biotechnology

Recommended Content

Cookies

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website. You can decide for yourself which categories you want to deny or allow. Please note that based on your settings not all functionalities of the site are available.

Further information can be found in our privacy policy.

Cookie Control

Customise your preferences for any tracking technology

The following allows you to customize your consent preferences for any tracking technology used to help us achieve the features and activities described below. To learn more about how these trackers help us and how they work, refer to the cookie policy. You may review and change your preferences at any time.

See the full cookie policy See the full privacy policy
More information

These trackers are used for activities that are strictly necessary to operate or deliver the service you requested from us and, therefore, do not require you to consent.

More information

These trackers help us to deliver personalized marketing content and to operate, serve and track ads.

More information

These trackers help us to deliver personalized marketing content to you based on your behaviour and to operate, serve and track social advertising.

More information

These trackers help us to measure traffic and analyze your behaviour with the goal of improving our service.

More information

These trackers help us to provide a personalized user experience by improving the quality of your preference management options, and by enabling the interaction with external networks and platforms.