Traceless isolation of killer T cells via DNA aptamers
DNA aptamers that specifically bind to the T-cell marker CD8 and that can be displaced by a complementary oligonucleotide enable the isolation, at high purity and yield, of CD8+ T cells for CAR-T cell therapies.
Published in Bioengineering & Biotechnology
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Chief Editor, Nature Biomedical Engineering, Nature Research
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Life Sciences > Biological Sciences > Biotechnology
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Nature Biomedical Engineering
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The cover illustrates the isolation of CD8+ T cells by magnetic microbeads functionalized with DNA aptamers that specifically bind to the T-cell marker CD8 and and that can be displaced by a complementary oligonucleotide.
See Kacherovsky et al.
Image credit: Hang Yu Lin