Today at Nature Reviews Methods Primers we celebrate the publication of our 100^th Primer article.

100 methods and techniques now have an easily accessible, broad introductory overview for newcomers. In our first three volumes, we have explored methods across the physical, biological, mathematical and social sciences, with Primers covering all aspects of the methodological workflow, including design, synthesis, fabrication, characterisation, computation and analysis.

Handling such a broad range of topics presents a unique challenge for the editorial team. A typical week can go from looking at microscopy images to checking a computer algorithm. As editors, we have been lucky to work with fantastic groups of authors and reviewers to ensure that we address the needs of each research field. Now, with over a million page views and thousands of citations in our first 2.5 years, we are pleased to see our efforts paying off and the impact our Primer articles have in the community.

Looking back on the journal launch in January 2021, one of our aims was to address the reproducibility crisis. The idea was that by providing a single, authoritative summary of a method, standards could be established. As noted in our one year anniversary editorial, some Primers have introduced new initiatives for reproducibility and data sharing. An example is the Primer on Bayesian statistics and modelling, which includes a checklist to avoid misuse of the method. Other examples include summaries of open access data and code repositories in ocean biogeochemical modelling and minimum information reporting for highly interdisciplinary methods, such as nanodelivery of nucleic acids.

Reaching 100 Primers would not be possible without the support of our art and production teams.

What is most unique about working on Nature Reviews Methods Primers is the vast amount of topics this journal covers. I could be spending the morning technically illustrating lasers and a cantilever for a Primer article on scanning probe microscopy, and in the afternoon, I could be working on a PrimeView and finessing an abstract version of the Mona Lisa to show how spatially offset Raman spectroscopy has use in art and conservation studies.

-  Sam Whitham, Art Director

Working on a new launch journal is both exciting and daunting. Combining the established Nature Reviews style with an individualized Primer stamp has provided unique challenges, but the journey has been a rewarding one. It has been incredible to see the variety of methods published so far, and I am excited to see what comes next.

– Rebecca Hill, Sub Editor

One of my proudest moments at NRMP was at a recent conference, where I saw someone reading one of our Primer articles to quickly familiarise themselves with a method before the session began. This is where the journal excels, as a launching point for researchers to start their journey with a particular method or technique. Having reached 100 Primers, we are far from finished. In the coming months and years, we hope to continue the success of our first 100 articles, expanding to more methods and emerging techniques.