Inflammation is a vital player in the metastatic process. Inflammatory molecules secreted by cells in the tumor microenvironment can foster cancer cell dissemination through affecting the infiltration of immune cells, promoting angiogenesis, and regulating the extracellular matrix. Inflammatory mediators can also make it easier for cells to exit the blood stream and seed in the metastatic site.

The open Collection Inflammation and metastasis invites original research exploring the relationship between inflammation and metastasis, with a focus on mechanistic studies underlying this relationship and studies identifying novel therapies targeting inflammation.

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