Behind the Paper: The High Financial Cost of Taking "Too Many" Medicines in Nigeria

By analyzing 2,000 prescription records alongside patient and clinician surveys at a Nigerian hospital, our study exposes the dangerous tipping point where polypharmacy transforms life-saving care into an unbearable out-of-pocket financial catastrophe.
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BioMed Central
BioMed Central BioMed Central

Prevalence and economic burden of polypharmacy in a secondary healthcare facility in North-Central Nigeria: a cross-sectional study

Background Polypharmacy, commonly defined as the concurrent use of five or more medications, is an increasing public health concern worldwide, particularly among patients with chronic diseases. Although the use of multiple medications may be clinically necessary, polypharmacy is associated with adverse drug reactions, poor adherence, increased healthcare utilization, and substantial financial burden. In low- and middle-income countries such as Nigeria, where healthcare financing depends largely on out-of-pocket payment, the economic impact of polypharmacy on patients can be considerable. This study assessed the prevalence and economic burden of polypharmacy among patients attending a secondary healthcare facility in North-Central Nigeria. Methods A cross-sectional study was conducted at Offa Specialist Hospital, Kwara State, Nigeria. The study comprised a retrospective review of 2,000 prescriptions issued between January and June 2025 to determine the prevalence of polypharmacy and a prospective questionnaire survey involving 100 patients and 50 healthcare providers conducted between July and August 2025 to assess medication-related financial burden and perceptions of polypharmacy. Results Polypharmacy was observed in 37.0% of reviewed prescriptions (740/2,000). Of the prescriptions reviewed, 25.0% contained 5–9 medications (major polypharmacy) and 12.0% contained 10 or more medications (excessive polypharmacy). Most prescriptions (63.0%) contained 2–4 medications. Among patients surveyed, 37% reported spending more than ₦20,000 monthly on medications, and 79% indicated that medication cost constituted a financial burden. 66% of patients reported skipping or reducing medications due to cost, while 78% required financial assistance to obtain prescribed drugs. Among healthcare providers, 84% frequently encountered patients taking five or more medications, and all providers agreed that polypharmacy significantly increases treatment cost. Conclusion Polypharmacy is prevalent and remains a significant prescribing concern in this secondary healthcare setting and imposes a substantial economic burden on patients. Strengthening medication review practices, promoting rational prescribing, and expanding health insurance coverage may help reduce unnecessary polypharmacy and its financial consequences in resource-limited settings.

When a patient walks into a clinic, receiving a prescription is supposed to be the first step toward healing. But what happens when that single visit ends with a prescription for five, eight, or more than ten different drugs at once? In low- and middle-income countries like Nigeria, where health insurance covers only a fraction of the population and healthcare is paid almost entirely out-of-pocket, taking multiple medications can transform a routine health check into a devastating financial crisis.

Our team set out to investigate this precise dilemma at Offa Specialist Hospital in Kwara State, Nigeria. We wanted to know: how widespread is polypharmacy in a secondary healthcare setting, and what does it actually cost the patients on the receiving end?

The Dual Realities: Prescription Records vs. Daily Survival

To get the full story, we combined two research perspectives: a retrospective review of 2,000 prescriptions and a prospective survey of 100 patients and 50 healthcare professionals

The Scale of the Problem: Over 37% of reviewed prescriptions met the criteria for polypharmacy (5 or more medications), with 12% involving "excessive polypharmacy" of 10 or more drugs. The average prescription contained 4.8 drugs. 

The Cost Barrier: Among surveyed patients, 37% spent over ₦20,000 per month on drugs, with an average expenditure of ₦18,600. For 79% of patients, these costs represented a major financial burden.

Dangerous Compromises: High costs forced 66% of patients to skip doses, reduce medication intake, or delay purchases. Additionally, 78% depended on financial help from family and friends just to pay for their prescriptions

Bridging the Gap: What Healthcare Providers See

The study revealed an overwhelming consensus among clinicians. Every single healthcare provider surveyed (100%) agreed that polypharmacy drives up treatment costs, and 84% noted that they frequently care for patients taking five or more medications. Crucially, 72% of providers recognized that some prescribed medications could be safely reduced through structured medication reviews

Our findings underline an urgent need to rethink prescribing habits. Addressing polypharmacy isn't just a clinical goal to avoid adverse drug interactions—it is an economic lifeline for patients navigating out-of-pocket healthcare. Integrating routine medication reviews, strengthening clinical pharmacology collaboration, and expanding universal health coverage are critical steps to ensuring that treating an illness doesn't cause a financial crisis.

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Follow the Topic

Pharmacoeconomics
Humanities and Social Sciences > Economics > Sector and Industry Studies > Health Economics > Pharmacoeconomics
Drug Safety and Pharmacovigilance
Life Sciences > Health Sciences > Public Health > Drug Safety and Pharmacovigilance
Health Policy
Life Sciences > Health Sciences > Public Health > Health Policy

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