Collection Overview

Scientific Reports has launched a Guest-Edited Collection on Primary immunodeficiency disorders.

Representing a group of over 450 rare inherited conditions, Primary Immunodeficiency Disorders (PIDs) are typically characterised by increased susceptibility to infections and dysregulation of the immune system. While the development and application of genetic panels has significantly advanced the identification and diagnosis of PIDs, our understanding of the underlying immunogenetics and pathogenesis remains limited. In particular, laboratory and clinical research in this field may focus on advances in diagnosis and treatment, characterisation of clinical phenotypes, PID pathogenesis, and investigations into undefined PIDs.

This will be a Collection of original research papers and will be open for submissions from all authors – on the condition that the manuscripts fall within the scope of the Collection and of Scientific Reports more generally. We are welcoming submissions until 9th January 2026.

Why is this Collection important? 

"Primary immunodeficiency disorders comprise a diverse group of rare inherited conditions that cause immune dysfunction and heightened susceptibility to infections, often leading to significant health challenges for patients. This Collection highlights research focused on uncovering their genetic and immunological foundations, improving diagnosis, and developing effective treatments to enhance patient outcomes and quality of life. " - Dr. Shelby Bollen

Why submit to a Collection? 

Collections like this one help promote high-quality science. They are led by Guest Editors, who are experts in their fields, and In-House Editors and are supported by a dedicated team of Commissioning Editors and Managing Editors at Springer Nature. Collection manuscripts typically see higher citations, downloads, and Altmetric scores, and provide a one-stop-shop on a cutting-edge topic of interest. 

Who is involved? 

Guest Editors:

• Rabih Halwani, University of Sharjah, Sharjah, United Arab Emirates
• Alexandra Kreins, University College London, London, UK; Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK 

Internal Team:

• In-House Editor: Shelby Bollen, Scientific Reports, Germany
• Commissioning Editor: Sophie Gray, Fully OA Brands, Springer Nature, UK
• Managing Editor: Libby Symons, Fully OA Brands, Springer Nature, UK

How can I submit my paper? 

Visit the Collection page to find out more about this Collection and how to submit your article.