Father’s adolescent body silhouette is associated with offspring asthma, lung function and BMI through DNA methylation

People whose fathers were overweight as teenagers had epigenetic markers associated with asthma, obesity and low lung function.
Go to the profile of Negusse Kitaba
Negusse Kitaba
Research Fellow, University of Southampton
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Nature
Nature Nature

Father’s adolescent body silhouette is associated with offspring asthma, lung function and BMI through DNA methylation - Communications Biology

Epigenome association study of father’s preconception body silhouette with offspring DNA methylation, providing mechanistic insight into how epigenetic inheritance impacts offspring obesity, asthma and lung function.
Graphic abstract
Epigenome wide association study of father 's body silhouette

Epigenome association study of fathers’ preconception body silhouette, provide mechanistic insight into how epigenetic inheritance impact his children’s obesity, asthma and lung function.Research published in Nature Communications Biology is the first human study to reveal the biological mechanism behind the impact of fathers’ early teenage obesity on their children.  https://www.nature.com/articles/s42003-025-08121-9.
Go to the profile of Negusse Kitaba
Negusse Kitaba
Research Fellow, University of Southampton

Follow the Topic

Obesity
Life Sciences > Health Sciences > Clinical Medicine > Diseases > Nutrition Disorder > Obesity
Epigenetics
Life Sciences > Biological Sciences > Genetics and Genomics > Epigenetics
Genetic Imprinting
Life Sciences > Biological Sciences > Genetics and Genomics > Epigenetics > Genetic Imprinting
DNA methylation
Life Sciences > Biological Sciences > Genetics and Genomics > Epigenetics > DNA methylation
Asthma
Life Sciences > Health Sciences > Clinical Medicine > Diseases > Respiratory Tract Diseases > Asthma
Genomics
Life Sciences > Biological Sciences > Genetics and Genomics > Genomics

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