Communications Biology
An open access journal from Nature Portfolio publishing high-quality research, reviews and commentary in all areas of the biological sciences, representing significant advances and bringing new biological insight to a specialized area of research.
Shifting the paradigm for non-contact anterior cruciate ligament rupture to emphasize intrinsic genetic risk in humans and dogs
Non-contact anterior cruciate ligament (ACL) rupture is a common injury. The underlying mechanism has long been mischaracterized as principally mechanical. Our work reveals that ACL rupture is a heritable, polygenic disease. This breakthrough challenges the causal paradigm and advances patient care.
Exploiting Temporal Correlation of Fortunate Single Molecules for Background-free Super-resolution Imaging
Fortunate molecules (molecules with long blinking cycles) hold the key to quantitative super-resolution imaging (high SBR and a PAR-shift towards a single molecule limit), a step towards economical, reliable, and universal SMLM.
Navigating New Territory in a Small Lab
The journey behind our recent paper was a long one, filled with hurdles and unexpected turns that we learned to navigate along the way. Working from a small lab with limited resources, we embarked on a project that introduced us to the complex and evolving field of biomolecular phase separation.
Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization
Activating the mevalonate (MVA) pathway increases bladder cancer (BLCA) spread. High MVA enzyme levels predict worse outcomes. Drugs like zoledronic acid or simvastatin blocking this pathway reduce cancer cell migration by affecting the protein RhoB. Targeting the MVA pathway could help treat BLCA.
Unveiling the 'hidden' effects of subclinical infection - a movement ecology perspective
Parasitism is one of the most ubiquitous strategies across ecosystems. Yet, wildlife researchers often assume animals are healthy and performing optimally. In reality, many carry 'hidden' infections with masked symptoms that nevertheless affect movement capacity, potentially impacting host fitness.
