Communications Biology
An open access journal from Nature Portfolio publishing high-quality research, reviews and commentary in all areas of the biological sciences, representing significant advances and bringing new biological insight to a specialized area of research.
Debunking de novo NAD+ Synthesis in C. elegans: Artifacts Arising from Impure Quinolinic Acid
Axenic culture system reveals that C. elegans lacks the necessary mechanisms for de novo synthesis of NAD+. Commercially available quniolinic acid products contain nicotinic acid impurity, potentially producing misleading information.
Shifting the paradigm for non-contact anterior cruciate ligament rupture to emphasize intrinsic genetic risk in humans and dogs
Non-contact anterior cruciate ligament (ACL) rupture is a common injury. The underlying mechanism has long been mischaracterized as principally mechanical. Our work reveals that ACL rupture is a heritable, polygenic disease. This breakthrough challenges the causal paradigm and advances patient care.
Exploiting Temporal Correlation of Fortunate Single Molecules for Background-free Super-resolution Imaging
Fortunate molecules (molecules with long blinking cycles) hold the key to quantitative super-resolution imaging (high SBR and a PAR-shift towards a single molecule limit), a step towards economical, reliable, and universal SMLM.
