The intricate dance of life, from a single fertilized egg to a complex organism, is orchestrated by a symphony of developmental mechanisms. Understanding these mechanisms, particularly in organ formation, is not only a fundamental pursuit in biology but also holds immense potential for regenerative medicine. The purpose of this collection is to shine a spotlight on the fascinating world of organogenesis, exploring the shared and unique strategies employed by diverse species to build their vital organs. This compilation of articles will serve as a valuable resource to promote innovation in the mechanisms of organ development in invertebrates.

Organ development is a complex and dynamic process that involves a myriad of genetic, molecular, cellular, and environmental factors. While invertebrates exhibit remarkable diversity in their body plans and organ systems, they often share conserved developmental pathways and regulatory networks. Although our knowledge of these aspects has progressed, much remains to be clarified about the relevant regulatory mechanisms. Based on integration of insights from model organisms and emerging non-model species, this collection provides a comprehensive perspective on the developmental mechanisms that shape invertebrate organs. It also encourages the translation of basic research findings into applications in regenerative medicine studies.

This collection brings together a collection of reviews and original research articles from leading experts in the field. We aim to provide a comprehensive overview of the current state of knowledge, highlight emerging trends, and spark new avenues of research in invertebrate organ development. Through unravelling the mysteries of how organs are built, we not only gain a deeper appreciation for the complexity of life but also pave the way for groundbreaking advancements in medicine and technology.

Keywords: development biology, development mechanism, invertebrate, organ

Numerous biomaterials have been developed for tissue regeneration, drug delivery and diagnostic applications. Although there has been great progress in material innovation and pre-clinical testing, there has been limited clinical translation of biomaterial-based therapeutics and devices. Several biological and technological challenges have contributed to this huge gap between pre-clinical and clinical success.

This collection aims to present some of the recent progress in the development of materials intended for various biomedical applications which includes drug delivery systems, diagnostic and therapeutic devices and tissue regeneration related to the theme of the International Conference on Clinical Translation of Biomaterial-based Therapeutics and Devices, ICBTD 2025.

We welcome submissions from the participants of the Conference held on 6-7 February 2025 at Somaiya Vidyavihar University, Mumbai, India to this special issue and mention the same in the cover letter.

Keywords:biomaterials, therapeutics, diagnostics, devices, tissue regeneration, delivery systems, clinical translation