The Clinical Practice topical collection aims to provide clinicians with the latest clinically relevant insights on a range of topics that would result in the enhancement of their knowledge and improvement of patient care. The topics may vary from clinical immunology and rheumatology to hematology, oncology and internal medicine in more general terms. The collection is open to submissions from experienced authors.

Myeloproliferative neoplasms (MPNs) encompass a diverse group of hematological malignancies characterized by the overproduction of blood cells due to dysregulation of hematopoiesis. This Collection seeks to explore the pathophysiological mechanisms underlying conditions such as polycythemia vera, essential thrombocythemia, and myelofibrosis. Understanding these disorders at the molecular and cellular levels is crucial for developing more effective diagnostic and therapeutic strategies, particularly as our knowledge of the genetic and epigenetic factors involved in MPNs continues to expand.

The significance of ongoing research in this field is highlighted by recent advances in targeted therapies and molecular diagnostics, which have the potential to transform patient outcomes. Innovations such as gene expression profiling and improved understanding of platelet biology have opened new avenues for treatment, enabling personalized medicine approaches that cater to individual patient needs. As the landscape of MPNs management evolves, it becomes increasingly vital to address challenges related to leukemia transformation and disease progression, ensuring that patients receive optimal care.

Future research in myeloproliferative neoplasms may lead to the identification of novel therapeutic targets and biomarkers that further enhance our ability to predict disease outcomes and tailor treatments. Additionally, advancements in gene editing technologies and immunotherapy could pave the way for groundbreaking strategies in disease management. By continuing to investigate the underlying mechanisms of these disorders, we can aspire to improve quality of life and survival rates for patients affected by MPNs.

Researchers are encouraged to submit their work to this Collection, which aims to showcase innovative research on the pathophysiology and therapeutic advancements in myeloproliferative neoplasms. We welcome studies that contribute to a deeper understanding of these conditions and explore new avenues for improved diagnosis and treatment.