Understanding the knowledge gap in dental stem cell therapy

A cross-sectional survey exploring Palestinian dentists’ knowledge, perceived barriers, and adoption attitudes toward dental stem cell therapy, with a focus on education, training needs, and cautious integration of regenerative dentistry.
Understanding the knowledge gap in dental stem cell therapy
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BioMed Central
BioMed Central BioMed Central

Exploring the knowledge gap in dental stem cell therapy: educational challenges and adoption attitudes among Palestinian dentists - BMC Medical Education

Background Dental stem cell therapy (DSCT) is a promising domain in regenerative dentistry, yet the knowledge base, perceived barriers, and adoption readiness among practicing dentists remain unclear. This study assessed knowledge, attitudes, perceived barriers, and willingness to adopt DSCT among Palestinian dentists. Methods We conducted a cross-sectional, web-based survey of licensed dentists in the West Bank (January–August 2024). Recruitment occurred via closed professional groups; one response per account was enforced. The knowledge index comprised six single-best multiple-choice questions (three options + “Don’t know”); scoring was 1 for correct and 0 for incorrect/“Don’t know” (range 0–6), classified as low (0–2), moderate (3–4), and high (5–6). Attitudes and ethical concerns were assessed using structured categorical items and Likert-type statements, and willingness to adopt DSCT was measured using a four-option item (“Yes,” “have reservations,” “not interested,” “No”), analysed as Yes vs. other responses. Bivariate associations used χ² with Cramér’s V; adjusted analyses used ordinal logistic regression for knowledge and binary logistic regression for willingness. Results Among 330 dentists, knowledge was low in 73.3%, moderate in 21.5%, and high in 5.2%; 69.7% reported willingness to adopt DSCT. Age was associated with higher knowledge (Cramér’s V 0.382; 95% CI 0.334–0.454). In adjusted analyses, older age independently predicted higher knowledge (e.g., > 50 vs. 23–30: aOR 8.88; 95% CI 1.87–42.05; p = 0.006). For willingness, orthodontists were less willing than general dentists (aOR 0.05; 95% CI 0.01–0.42), whereas a higher likelihood of pursuing continuing education predicted willingness (aOR 3.54; 95% CI 1.60–7.79). The most cited barriers were lack of knowledge (43.9%), cost (26.1%), and ethical concerns (14.5%). Conclusions Most dentists demonstrated low DSCT knowledge but substantial willingness to adopt. Targeted education (undergraduate and continuing), practical guidance, and clearer regulatory direction may help address knowledge gaps and perceived barriers in Palestine.

Dental stem cell therapy is often discussed as a potential direction in regenerative dentistry. Yet for me, this study was never only about stem cells, education, or professional attitudes. It was also about a practical question: how prepared are practicing dentists to understand, evaluate, and potentially adopt emerging regenerative approaches in real clinical settings?

This question became the starting point for our recently published article in BMC Medical Education. As a dentist and researcher working in regenerative dentistry and dental stem cells, I was interested not only in the scientific promise of dental stem cell therapy, but also in the educational gap that may shape how such therapies are understood by practicing clinicians.

In contexts where access to specialized training, institutional support, and regulatory guidance may be limited, understanding professional knowledge gaps becomes especially important. Scientific progress alone is not enough if clinicians do not have the educational tools needed to interpret and apply emerging therapies responsibly.

The study focused on Palestinian dentists and explored their knowledge, attitudes, perceived barriers, and willingness to adopt dental stem cell therapy. Using a cross-sectional, web-based survey, we assessed factual knowledge, adoption attitudes, ethical concerns, perceived obstacles, and interest in future education and training.

One of the clearest findings was that knowledge remained limited among many respondents, even though willingness to adopt dental stem cell therapy was relatively high. This contrast felt important to us. It suggested that there is genuine interest and openness toward innovation, but interest alone is not enough for safe and responsible implementation. Clinicians also need structured education, clear professional guidance, and access to evidence-based training.

The most commonly reported barrier was lack of knowledge, followed by cost and ethical concerns. These findings suggest that the challenge is not only scientific or technical. It is also educational, regulatory, and practical. For dental stem cell therapy to move responsibly toward clinical contexts, dentists need more than awareness; they need a clear understanding of indications, limitations, safety considerations, regulatory boundaries, and ethical responsibilities.

At the same time, we were careful not to overinterpret the findings. This was a cross-sectional survey, not a measure of clinical competence or actual adoption behavior. Recruitment was conducted through closed professional online groups, which may have reached dentists who were more digitally connected or more education-oriented. Therefore, the results should be interpreted as a context-specific snapshot of knowledge, attitudes, and perceived barriers among the surveyed Palestinian dentists, rather than as a definitive national assessment.

For me, the value of this work lies in highlighting a practical gap between scientific progress and professional readiness. Dental stem cell therapy may hold promise, but responsible translation requires education before implementation. Undergraduate curricula, continuing education programs, and clearer regulatory guidance may all play important roles in preparing dentists to engage with regenerative therapies in a safe and evidence-informed way.

I hope this study contributes to discussions around dental education, regenerative dentistry, and the responsible adoption of emerging therapies, especially in settings where access to specialized training and regulatory guidance may still be limited. Identifying educational gaps is not a small matter; it is one step toward supporting future healthcare education and preparedness.

Published article:
Zahedah R, Jaber M, Dinç B. Exploring the knowledge gap in dental stem cell therapy: educational challenges and adoption attitudes among Palestinian dentists. BMC Medical Education. 2026;26:535. https://doi.org/10.1186/s12909-026-08880-x

Follow the Topic

Dental Education
Life Sciences > Health Sciences > Clinical Medicine > Dentistry > Dental Education
Regenerative Medicine and Tissue Engineering
Life Sciences > Biological Sciences > Biotechnology > Regenerative Medicine and Tissue Engineering
Continuing professional development in dentistry
Life Sciences > Health Sciences > Clinical Medicine > Dentistry > Dental Education > Continuing professional development in dentistry
Translational Research
Life Sciences > Health Sciences > Biomedical Research > Translational Research
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