Go to the profile of Alejandro Brenes

Alejandro Brenes

Wellcome Early Career Fellow, University of Edinburgh
  • United Kingdom

About Alejandro Brenes

I graduated from my PhD at the University of Dundee in 2023 under the supervision of Prof. Cantrell and Prof. Lamond. My work focussed on using large-scale proteomics and computational biology to characterise the murine and human immune system, with a focus on murine T cells and human neutrophils. This led me to create the Immunological Proteome Resource (immpres.co.uk).

In 2024 I started working as a postdoctoral computational biologist within the Walmsley Group at the Centre for Inflammation Research, part of the University of Edinburgh. My research is now focussed on the proteomic characterisation of human granulocytes by leveraging mini-bulk and single cell proteomic workflows with the aim to define neutrophil and granulocyte functional heterogeneity, functional capacities and phenotypes in both homeostasis and chronic inflammatory disease.

In November 2025 I was awarded a Wellcome Trust Early Career Award to carry out my independent research to define neutrophil functional heterogeneity & dysfunction in chronic obstructive pulmonary disease (COPD) using single cell proteomics.

Intro Content

Nature Communications
Behind the Paper

Single cell proteomics of human neutrophils in glioblastoma

Neutrophils infiltrate glioblastomas with the capacity to engage pro/anti tumoural responses. Here we developed single cell proteomic workflows to stratify neutrophil heterogeneity by function. This work provides a platform to study neutrophil proteomes with single cell resolution in glioblastoma.

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Behind the Paper

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