Stem cell-like CD8 T cells are at the heart of the anti-tumor response induced by PD-L1/TGFβ dual blockade in immune excluded tumors
In depth analysis of the CD8 T cells infiltrating an immune excluded tumor model revealed the presence of stem cell-like CD8 T cells that expanded in situ upon anti-PD-L1/TGFβ combination therapy fueling an efficient and IFNγ dependent anti-tumor response.
