Plasminogen-Apple-Nematode (PAN) domain: A new target to modulate the HGF/c-MET signaling in cancers.
Our newly published paper suggests that four cysteine residues at the core of the HGF PAN domain are essential for its binding with the proto-oncogenic receptor c-MET and the subsequent activation of the downstream signaling cascade. Debjani Pal, Kuntal De, and Wellington Muchero.
