Go to the profile of Haeun Yang

Haeun Yang (She/Her)

Ph.D. , Seoul National University
  • Korea (Republic of)

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Re-sensitizing CML to Imatinib: Dual Targeting of HDACs and BCR-ABL with Martinostat
Clinical Epigenetics
Behind the Paper

Re-sensitizing CML to Imatinib: Dual Targeting of HDACs and BCR-ABL with Martinostat

Chronic Myeloid Leukemia (CML), driven by BCR-ABL, accounts for 15% of adult leukemias. While TKIs like imatinib improved outcomes, resistance remains a challenge. We demonstrate for the first time that the HDAC inhibitor martinostat shows potent activity in both TKI-sensitive and -resistant CML.

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