A recyclable stereoauxiliary aminocatalyzed strategy for one-pot synthesis of indolizine-2-carbaldehydes
We propose in this study an iminium ion/enamine tandem sequence that could efficiently overcome energy barriers encountered in Michael and aldol reactions during [3+2] annulations of acyl pyridines and α,β-unsaturated aldehyde for the construction of diverse indolizine-2-carbaldehydes.