Behind the Paper: How IL-6 shapes the anti-tumor battle and supports TGFβ immune modulatory vaccines in pancreatic cancer
The study highlights that the antitumor efficacy of TGFβ-specific T cells in pancreatic cancer critically depends on IL-6 signaling. IL-6R blockade compromises the immune response by reducing vaccine-induced T-cell infiltration as well as increasing immunosuppressive tumor-associated macrophages.
