Cellular & Molecular Immunology Cellular & Molecular Immunology

Cellular & Molecular Immunology

A monthly journal from the Chinese Society of Immunology and the University of Science and Technology of China, covering both basic immunology research and clinical applications.

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Cellular & Molecular Immunology
Behind the Paper

Behind the Paper: How IL-6 shapes the anti-tumor battle and supports TGFβ immune modulatory vaccines in pancreatic cancer

The study highlights that the antitumor efficacy of TGFβ-specific T cells in pancreatic cancer critically depends on IL-6 signaling. IL-6R blockade compromises the immune response by reducing vaccine-induced T-cell infiltration as well as increasing immunosuppressive tumor-associated macrophages.
Go to the profile of Mads Hald Andersen +1
Mads Hald Andersen and 1 other
Dec 17, 2024
Cellular & Molecular Immunology
Behind the Paper

Pedigree analysis of a POLD1 germline mutation in urothelial carcinoma shows a close association between different mutation burdens and overall survival

We found a bladder cancer family in which germline mutations of POLD1 and somatic mutations of FGFR3 were prevalent. We studied the changes in the immune microenvironment in patients with this mutation in our cohort and a TCGA cohort and predicted the prognosis of patients with this subtype.
Go to the profile of Yu Xiao +3
Yu Xiao and 3 others
Oct 10, 2024
Cellular & Molecular Immunology
Behind the Paper

CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity

We sought to understand the molecular basis underlying the metabolic flexibility of activated CD8+ T cells, with particular focus on the Cap-Binding Complex adaptor protein ARS2. In doing so, we uncovered a novel link between CD28 costimulation, ARS2, alternative splicing, and anti-tumor immunity.
Go to the profile of G. Aaron Holling
G. Aaron Holling
Feb 02, 2024

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