Cellular & Molecular Immunology
A monthly journal from the Chinese Society of Immunology and the University of Science and Technology of China, covering both basic immunology research and clinical applications.
CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity
We sought to understand the molecular basis underlying the metabolic flexibility of activated CD8+ T cells, with particular focus on the Cap-Binding Complex adaptor protein ARS2. In doing so, we uncovered a novel link between CD28 costimulation, ARS2, alternative splicing, and anti-tumor immunity.
“A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells”.
In this paper published in Cellullar & Molecular Immunology by Martín-Cruz L/Viñuela M et al (doi:10.1038/s41423-023-01096-6), we uncover novel molecular mechanisms by which heparan sulfate-related structures associated with tumor cells promote the generation of functional Tregs in cancer.
A subpopulation of CD146+ tumor-associated macrophage
A subpopulation of CD146+ tumor-associated macrophage enhances the anti-tumor activity.
The epidermal immune microenvironment plays a dominant role in psoriasis development, as revealed by mass cytometry
Behind Paper：
The epidermal CD1c+CD11b+ cDC2s poised in the psoriasis perilesional skin, prepare the tissue and initiate inflammation，co-work with CD207+CD11chi LCs and CD5+ T cells in the psoriatic epidermis.
