Stereoselective conjugate cyanation of enals by combining photoredox and organocatalysis
By combining asymmetric organocatalysis and photoredox catalysis, we report an “umpolung” strategy for the first enantioselective β-cyanation of enals without formation of cyanohydrin. This strategy also enabled asymmetric formation of 1,6-dicarbonyl compounds through cross-electrophile coupling.