Oncometabolite D-2-hydroxyglutarate—dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia
Cancer cachexia is characterized by weight loss and skeletal muscle wasting. The up-regulation of catabolism and down-regulation of anabolism result in concometabolite accumulation. This study focused on genetic mutation-mediated metabolic reprogramming in cancer cachexia progression.
