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A few highlights from the paper:
• Key finding: The LINC01432–CELF2 axis (Long non-coding RNA-protein interaction) suppresses apoptosis in multiple myeloma, highlighting a novel mechanism of disease progression.
• Approach: Combined RNA-seq profiling, ChIRP/iCLIP pulldown assays, and CRISPR-mediated functional assays identified LINC01432 as a top lncRNA associated with poor prognosis. CRISPR-mediated knockdown of LINC01432 expression results in upregulation of genes associated with interferon-α/γ responses and increases apoptosis.
• Significance & future steps: Targeting the LINC01432–CELF2 interaction may offer a new therapeutic dimension for treatment-resistant multiple myeloma.