Dr. Rudong Li used to be a postdoctoral researcher at Indiana University–Purdue University Indianapolis (IUPUI) and now is the Advanced Bioinformatics Analyst at the Department of Medical and Molecular Genetics (MMGE), Indiana University School of Medicine (IUSM). His area of research includes human, molecular and statistical genetics; and his research focuses are regulatory variants and RNA alternative splicing in complex diseases, such as alcohol use disorder and Alzheimer’s disease. He has an important contribution in creating regSNPs-intron, the prediction tool for disease-causing intronic variants. He also played a critical role in developing the RNA sequencing assay for detecting SNP-induced aberrant splicing, ASSET-seq. As a long-term goal in scientific research, he persists in investigating the role of RNA alternative splicing or aberrant splicing in complex disease. For example, whether splicing or mis-splicing events can be hallmarks in disease; and which splicing events genetically impact the disease. Especially of interests, Dr. Rudong Li’s major research endeavors are on the link of gene splicing changes, such as skipped exons and retained introns in brain tissues, to the development of disease.