Molecular Psychiatry
This journal publishes work aimed at elucidating biological mechanisms underlying psychiatric disorders and their treatment, with emphasis on studies at the interface of pre-clinical and clinical research.
Behind the paper: ADNP is essential for sex-dependent hippocampal neurogenesis, through male unfolded protein response and female mitochondrial gene regulation
Surprisingly, dramatically different molecular pathways regulate adult neurogenesis in males and females. Importantly, these pathways are strongly impacted by the major autism/intellectual disability gene, ADNP and corrected by the ADNP neuroprotective site, the investigational drug davunetide.
Aging-dependent loss of functional connectivity in a mouse model of Alzheimer’s disease and reversal by mGluR5 modulator
Alzheimer’s disease is challenging to tackle: it can affect the brain years before symptoms like memory loss arise. Yet, this slow progress gives us a long window where early detection could slow or stop its progression. Our study dives into how brain imaging and mouse models can help us get there.
New tricks from old drugs: repurposing the 80s
A paper in Molecular Psychiatry describes a new cell biological mechanism regulated by antidepressants, showing how a single dose of a drug fluvoxamine may open up the brain for drug delivery. Can this finding signal the beginning of a brand new career for the 30+ year-old drugs?
