Molecular Psychiatry
This journal publishes work aimed at elucidating biological mechanisms underlying psychiatric disorders and their treatment, with emphasis on studies at the interface of pre-clinical and clinical research.
Decoding Anxiety in Down Syndrome: A Genomic and AI-Powered Exploration
Our study publisehd on Molecular Psychiatry on May 24th 2025, harnesses deep learning and whole-genome sequencing to uncover unique genetic markers of anxiety in children with Down syndrome, offering insights into tailored diagnostics and interventions.
Behind the paper: ADNP is essential for sex-dependent hippocampal neurogenesis, through male unfolded protein response and female mitochondrial gene regulation
Surprisingly, dramatically different molecular pathways regulate adult neurogenesis in males and females. Importantly, these pathways are strongly impacted by the major autism/intellectual disability gene, ADNP and corrected by the ADNP neuroprotective site, the investigational drug davunetide.
Aging-dependent loss of functional connectivity in a mouse model of Alzheimer’s disease and reversal by mGluR5 modulator
Alzheimer’s disease is challenging to tackle: it can affect the brain years before symptoms like memory loss arise. Yet, this slow progress gives us a long window where early detection could slow or stop its progression. Our study dives into how brain imaging and mouse models can help us get there.
