Steven Grossman

Professor, University of Southern California
  • United States of America

Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma

Tracking down targets of the oncogenic epigenetic regulator C-terminal Binding Protein in a mouse pancreatic cancer (PDAC) model led us to ErbB3, highly expressed in up to 60% of PDAC, and the possibility for precision therapy in ErbB3+ PDAC using FDA-approved or novel anti-ErbB2/3 agents.
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Steven Grossman and 1 other
Nov 24, 2023