A peer-reviewed open access online journal that publishes articles exploring mechanistic insight and molecular basis of cancer and related phenomena. It seeks to promote diverse and integrated areas of molecular biology, cell biology, oncology, and genetics.

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Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma

Tracking down targets of the oncogenic epigenetic regulator C-terminal Binding Protein in a mouse pancreatic cancer (PDAC) model led us to ErbB3, highly expressed in up to 60% of PDAC, and the possibility for precision therapy in ErbB3+ PDAC using FDA-approved or novel anti-ErbB2/3 agents.
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Steven Grossman and 1 other
Nov 24, 2023