Behind the ALS - How does the protein SOD1 convert between physiological and pathological states?
ALS is a famous neurodegenerative disease. Misfolded SOD1 has been linked to both familial and sporadic ALS. Here, we present a cryo-EM structure of SOD1 fibrils, providing insights into the conversion of SOD1 from its immature form into an aggregated form during pathogenesis of ALS.
