Breakthrough in Stereoselective C(sp³)–H Alkylation: Nickel Catalysis Unlocks Efficient Synthesis of Chiral Heterocycles
The Kong group report a Ni-catalyzed enantioselective C(sp³)–H alkylation of saturated heterocycles using olefins, enabling efficient construction of chiral C(sp³)–C(sp³) bonds. Applications include late-stage drug diversification and concise syntheses of bioactive alkaloids.