Beyond abundance: What HeLa's genetic drift reveals about how cells buffer and adapt
Protein abundance alone often does not explain a phenotype. We combined signaling activity, transcription factor activity, and protein complex assembly state instead, and used a panel of genetically diverse HeLa cell lines to test whether this gives a more mechanistic picture of cell state.
New ways to control blood vessel growth in eye disease
In a model of abnormal eye vessel growth, removing ZEB1 made vessels grow more and become leakier. The study suggests ZEB1 controls vessel quality, not just vessel growth.
