Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Chemistry
Structure of human mGlu3-arrestin complex
In this paper, we reported the structures of two mGlu3-βarr1 complex with 2:1 and 2:2 stoichiometries. The mGlu3 in an inactive conformation engages βarr1 through phosphorylated C-terminal tail and intracellular loops.
Teff: The Ancient Grain with a Modern Mission
Teff, an ancient cereal grain that has enormous potential to influence the future of sustainable agriculture and food security. Native to Ethiopia, teff has long been a staple crop, but it has been largely ignored and underutilized on the international scene.
Extending Certified Spectral Fluorescence Standards for the Calibration and Performance Validation of Fluorescence Instruments to the NIR – Closing the Gap from 750 nm to 940 nm with Two Novel NIR Dyes
Fluorescence methods provide spectral, intensity, polarization, and lifetime information, which contain sample- and instrument-specific contributions. Fluorescence data, comparable across instruments and laboratories, require validated calibration procedures and certified fluorescence standards.
Breakthrough in Stereoselective C(sp³)–H Alkylation: Nickel Catalysis Unlocks Efficient Synthesis of Chiral Heterocycles
The Kong group report a Ni-catalyzed enantioselective C(sp³)–H alkylation of saturated heterocycles using olefins, enabling efficient construction of chiral C(sp³)–C(sp³) bonds. Applications include late-stage drug diversification and concise syntheses of bioactive alkaloids.
A glycan that performs catalysis
We reported a synthetic glycan sequence capable of catalyzing a chemical reaction. The design features an aromatic recognition site along with a reactive functional group connected via a folded glycan turn, facilitating the recruitment and Pictet-Spengler functionalization of an aromatic moiety.
Nanoscale Reference and Test Materials for the Validation of Characterization Methods for Engineered Nanomaterials – Current State, Limitations and Needs
Engineered nanomaterials (NMs) of different material composition, morphology, and surface chemistry are widely used in material and life sciences. For NM quality control and risk assessment, NM key properties must be characterized with validated methods, requiring reference materials (RMs).
