For Methylation Sequencing, The Cancer Is In The Details
Colorectal cancer (CRC) is a disease of subtle progression and devastating impact. With each step in its progression, survival odds decrease, plummeting from 91.5% in stage I to 16.2% in stage IV [1]. It’s clear that early detection of CRC is both critical and challenging.
Structure-function and mechanistic analyses of a nickel-dependent sulfonamide synthase
A cupin superfamily enzyme SbzM catalyzes the formation of sulfonamide moiety in the biosynthesis of a sulfonamide natural antibiotic altemicidin. Here, we report the structure-function and mechanistic analyses of AmSbzM by in vitro characterization, crystallization, mutagenesis and calculations.
The Story Behind the Paper: In vitro antimalarial activity of phytochemicals from Bombax costatum via inhibition of β-hematin formation
My colleague Hassan and I have collaborated since our MSc (2016), united by a shared mission: fighting malaria. Growing up in Nigeria, we saw its devastating toll. With Africa bearing 70% of global cases, we knew this was where we belonged
