Behind the Paper

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Shifting the paradigm for non-contact anterior cruciate ligament rupture to emphasize intrinsic genetic risk in humans and dogs

Non-contact anterior cruciate ligament (ACL) rupture is a common injury. The underlying mechanism has long been mischaracterized as principally mechanical. Our work reveals that ACL rupture is a heritable, polygenic disease. This breakthrough challenges the causal paradigm and advances patient care.
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Peter Muir and 1 other
Jan 14, 2025