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Therapeutic extracellular vesicles produced at scale

A cellular-nanoporation method produces large quantities of exosomes containing therapeutic mRNAs and targeting peptides that restore tumour-suppressor function in mice with orthotopically implanted phosphatase and tensin homologue (PTEN)-deficient brain gliomas.
Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research
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Nature
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Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation - Nature Biomedical Engineering

A cellular-nanoporation method produces large quantities of exosomes containing therapeutic mRNAs and targeting peptides that restore tumour-suppressor function in mice with orthotopically implanted phosphatase and tensin homologue (PTEN)-deficient brain gliomas.
Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research

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Go to the profile of Pep Pàmies
Pep Pàmies
about 6 years ago

The cover illustrates the production, via cellular nanoporation, of large quantities of extracellular vesicles loaded with endogenously transcribed therapeutic mRNAs and targeting peptides.

See Yang, Z. et al.

Image: Ella Marushchenko. Cover design: Alex Wing

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Biotechnology
Life Sciences > Biological Sciences > Biotechnology

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