Traceless isolation of killer T cells via DNA aptamers
DNA aptamers that specifically bind to the T-cell marker CD8 and that can be displaced by a complementary oligonucleotide enable the isolation, at high purity and yield, of CD8+ T cells for CAR-T cell therapies.
Published in Bioengineering & Biotechnology
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Chief Editor, Nature Biomedical Engineering, Nature Research
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Life Sciences > Biological Sciences > Biotechnology
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Nature Biomedical Engineering
This journal aspires to become the most prominent publishing venue in biomedical engineering by bringing together the most important advances in the discipline, enhancing their visibility, and providing overviews of the state of the art in each field.
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The cover illustrates the isolation of CD8+ T cells by magnetic microbeads functionalized with DNA aptamers that specifically bind to the T-cell marker CD8 and and that can be displaced by a complementary oligonucleotide.
See Kacherovsky et al.
Image credit: Hang Yu Lin