Behind the Paper

Blood clotting and tissue healing

The number of blood clots in society is expected to double by 2050. The risk of blood clotting increases significantly after injury, surgery, or leg immobilization. However, the effects of blood clots on tissue healing and the underlying regulatory mechanisms remain largely unknown.
Go to the profile of Paul Ackermann
Paul Ackermann
Professor, Karolinska Institutet
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Nature
Nature Nature

Novel tissue biomarker candidates to predict both deep venous thrombosis and healing outcome after Achilles tendon rupture - Scientific Reports

Scientific Reports - Novel tissue biomarker candidates to predict both deep venous thrombosis and healing outcome after Achilles tendon rupture

​A recent study investigated the occurrence of deep venous thrombosis (DVT)—a serious condition where blood clots form in deep veins—in patients who suffered Achilles tendon ruptures (ATR). The researchers aimed to identify tissue biomarkers that could predict both DVT development and long-term patient outcomes.

The study found specific biomarkers in tissue samples from ATR patients that were associated with a higher risk of developing DVT. These biomarkers could potentially serve as early warning signs, allowing for timely interventions to prevent complications. Additionally, they found that these biomarkers were linked to poorer long-term outcomes in patients, suggesting they could also help predict recovery trajectories.​

This research underscores the need to develop effective blood clot prevention strategies to improve both patient recovery and overall outcomes after injuries.

Go to the profile of Paul Ackermann
Paul Ackermann (He/Him)
Professor, Karolinska Institutet

  • Prof. P.W. Ackermann is focusing his research on neuro-vascular regulation of venous thromboembolism (blood clots), pain and musculo-skeletal tissue repair.  Physical inactivity is one of the greatest threats to health in modern times, contributing to blood clots, muscle loss, pain, obesity, and diabetes. Orthopedic patients face even greater risks due to injuries, surgeries, and prolonged periods of leg immobilization. In our research group, we aim to uncover the molecular mechanisms underlying complications such as blood clotting, impaired healing, and pain. Additionally, we are developing innovative, targeted strategies to prevent these complications by stimulating blood flow and nerve activity during periods of inactivity.

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Follow the Topic

Health and Illness
Life Sciences > Health Sciences > Health Care > Quality of Life Research > Health and Illness
Cardiovascular Diseases
Life Sciences > Health Sciences > Clinical Medicine > Diseases > Cardiovascular Diseases

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