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A Mendelian randomization (MR) study concluded that vitamin C was not effective for pneumonia. We showed that the MR study corresponds to the comparison of two groups with similar vitamin C levels of 47.3 vs. 52.7 μM, whereas the plasma vitamin C level range in the population is from 10 to 100 μM.

Harri Hemilä

Jan 10, 2023

European Journal of Clinical Nutrition

Behind the Paper

Vitamin C: abrupt termination may increase mortality of sepsis patients

The recent LOVIT trial of vitamin C for sepsis patients found that mortality was increased in patients randomized to the vitamin C group. In a re-analysis we show that mortality was increased only after the 4-day vitamin C administration was terminated, but not during the vitamin C administration.

Harri Hemilä

Jan 01, 2023

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Research Communities by Springer Nature

Harri Hemilä (He/Him)

Mendelian randomization can lead to flawed conclusions about the effects of vitamin C

Vitamin C: abrupt termination may increase mortality of sepsis patients